Abstract
Aim: This study was undertaken to investigate the hepatoprotective effect of Coustus saussura lappa versus liver toxicity induced by deltamethrin exposure. Experimental design: sixty adult male albino rats rattus norvegicus (150-180 gm) were divided into 6 groups treated for 28 days as; G1 control group, G2 (CT = coustus 300 mg/kg), G3 (DH = high dose deltamethrin 1/15 LD50; 4 m/kg), G4 (CTDH), G5 (DL = low dose deltamethrin 1/30 LD50; 2 mg/kg), G6 (CTDL). Results: showed remarkable elevation in plasma liver biomarkers; alanine aminotransferase (ALT), aspartate aminotransferase (AST) alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) in both deltamethrin treated groups, as well as slight elevation total plasma proteins. These results are consequence to the recorded significant reduction in the defence system biomarkers (SH-protein) and antioxidant enzymes; superoxide dismutase (SOD), catalase and detoxifying enzyme glutathione s-transfearse (GST). Degeneration in hepatocyets with congestion in the central veins was recorded in liver tissues. However supplementation with 300 mg/kg aqueous extract of cousts saussura lappa induced partial counteract in the above tested parameters especially in CTDL group. In conclusion: treatment with aqueous extract of saussura lappa induced early improvement in injured liver that promise better results on longer repeated use.