Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Mohamad Mohty; Florent Malard; Manuel Abecasis; Erik Aerts; Ahmed S. Alaskar; Mahmoud Aljurf; Mutlu Arat; Peter Bader; Frederic Baron; Grzegorz Basak; Ali Bazarbachi; Didier Blaise; Fabio Ciceri; Selim Corbacioglu; Jean-Hugues Dalle; Fiona Dignan; Takahiro Fukuda; Anne Huynh; Jurgen Kuball; Silvy Lachance; Hillard Lazarus; Tamas Masszi; Mauricette Michallet; Arnon Nagler; Mairead NiChonghaile; Shinichiro Okamoto; Antonio Pagliuca; Christina Peters; Finn B. Petersen; Paul G. Richardson; Tapani Ruutu; Wael Saber; Bipin N. Savani; Robert Soiffer; Jan Styczynski; Elisabeth Wallhult; Ibrahim Yakoub-Agha; Rafael F. Duarte; Enric Carreras

doi:10.1038/s41409-019-0705-z

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Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

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Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Mohamad Mohty, Florent Malard, Manuel Abecasis, Erik Aerts, Ahmed S. Alaskar, Mahmoud Aljurf, Mutlu Arat, Peter Bader, Frederic Baron, Grzegorz Basak, …

Bone marrow transplantation (Basingstoke), Vol.55(3), pp.485-495

01/03/2020

DOI: https://doi.org/10.1038/s41409-019-0705-z

PMCID: PMC7051913

PMID: 31576023

Abstract

Haematological diseases

Therapeutics

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the most severe forms result in multiorgan dysfunction and are associated with a high mortality rate (>80%). Therefore, careful surveillance may allow early detection of SOS/VOD, particularly as the licensed available drug is proven to be effective and reduce mortality. The aim of this work is to propose an international consensus guideline for the treatment and prevention of SOS/VOD in adult patients, on behalf of an international expert group.

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Title: Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group
Creators - without role: Mohamad Mohty - Hôpital Saint-Antoine
Florent Malard - Hôpital Saint-Antoine
Manuel Abecasis - IPO Porto
Erik Aerts - University Hospital of Zurich
Ahmed S. Alaskar - King Abdullah International Medical Research Center
Mahmoud Aljurf - King Faisal Specialist Hospital & Research Centre
Mutlu Arat - Istanbul Florence Nightingale Hospital
Peter Bader - Goethe University Frankfurt
Frederic Baron - University of Liège
Grzegorz Basak - Medical University of Warsaw
Ali Bazarbachi - American University of Beirut
Didier Blaise - Inserm
Fabio Ciceri - IRCCS Ospedale San Raffaele
Selim Corbacioglu - University of Regensburg
Jean-Hugues Dalle - Délégation Paris 7
Fiona Dignan - Manchester University NHS Foundation Trust
Takahiro Fukuda - HSCT Division, National Cancer Center Hospital, Tokyo, Japan
Anne Huynh - University Cancer Institute Toulouse Oncopole
Jurgen Kuball - University Medical Center Utrecht
Silvy Lachance - Hôpital Maisonneuve-Rosemont
Hillard Lazarus - Case Western Reserve University
Tamas Masszi - Unified Szent István and Szent László Hospital
Mauricette Michallet - Hôpital Lyon Sud
Arnon Nagler - Sheba Medical Center
Mairead NiChonghaile - Trinity College Dublin
Shinichiro Okamoto - Keio University
Antonio Pagliuca - King's College Hospital
Christina Peters - 1090 Vienna, Austria
Finn B. Petersen - LDS Hospital
Paul G. Richardson - Mayo Clinic
Tapani Ruutu - Helsinki University Hospital
Wael Saber - Medical College of Wisconsin
Bipin N. Savani - Vanderbilt University Medical Center
Robert Soiffer - Dana-Farber Cancer Institute
Jan Styczynski - Collegium Medicum in Bydgoszcz
Elisabeth Wallhult - Sahlgrenska University Hospital
Ibrahim Yakoub-Agha - University of Lille
Rafael F. Duarte - Hospital Universitario Puerta de Hierro Majadahonda
Enric Carreras - Josep Carreras Leukaemia Research Institute
Publication Details: Bone marrow transplantation (Basingstoke), Vol.55(3), pp.485-495
Publisher: Nature Publishing Group UK
Identifiers: 9921691008331
Academic Unit: King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article