Abstract
Nowadays, considerable interest has been expressed in using oil/metal oxide hybrid bionanocomposite, particularly organic/inorganic, to engineer different biomedical applications. The fabricated Oleum cumini oil/PVP/MgO bionanocomposite in this study was characterized using different spectroscopic and microscopic techniques as well as a thermal stability study. The obtained results proved excellent dispersion of MgO nanoparticles in the PVP-Oleum cumini oil matrix with particle size 50-60 nm. The green synthesized Oleum cumini oil/PVP/MgO bionanocomposite was evaluated for antimicrobial, antioxidant and anticancer activities. The prepared bionanocomposite displayed excellent antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida tropicalis, and Candida Glabrata. Also, the bionanocomposite showed anticancer activity against the pancreatic cancer cell lines (PANC-1), and exhibited significant antioxidant effects against the DPPH and ABTS scavenging free radicals. Conclusively, the fabricated Oleum cumini oil/PVP/MgO bionanocomposite combine the benefits of Oleum cumini oil and MgO, and thus might hold a great promise for biomedical applications in the near future.