Abstract
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•MgO/ZnO nanocomposite was synthesized.•The physical and chemical properties of MgO/ZnO nanocomposite were confirmed by spectroscopic and microscopic techniques.•MgO/ZnO (CTB-TPB-MgO/ZnO) nanocomposite coated wire sensor for cytarabine determination was suggested.•High selectivity and ultra sensitivity for the determination of cytarabine with wide linearity have been recorded.•The outcomes were compared with those obtained from various addressed analytical techniques.
Recent attention has been developed towards the use of metal oxide nanocomposites as significant and electroactive nanomaterials in potentiometric and sensing applications. Two potentiometric cytarabine (CTB) coated wire sensors were fabricated using cytarabine-tetraphenyl borate (CTB-TPB), a modified cytarabine-tetraphenyl borate decorated with MgO/ZnO nanocomposite (CTB-TPB-MgO/ZnO) ion associates, polyvinyl chloride (PVC) and o-nitrophenyloctyl ether (o-NPOE) as electroactive materials for conventional and modified sensors, polymeric matrix and fluidizer agent, respectively. The functionalized CTB-TPB-MgO/ZnO polymeric sensor displayed Ultra potentiometric selectivity and high sensitivity for the determination of CTB within 1.0 × 10−10-1.0 × 10−2 mol L−1 solutions, correlation coefficient (r2 = 0.9999), lower detection limit 4.9 × 10-11 mol L−1 and least regression equation EmV = (57.433 ± 0.2) log [CTB] + 673.16 mV. The obtained results were compared to the conventional CTB-TPB type of 1.0 × 10-6-1.0 × 10−2 mol L−1 linear concentration range, correlation coefficient (r2 = 0.9995), lower detection limit 5.0 × 10−7 mol L−1 and least regression equation EmV = (52.633 ± 0.6) log [CTB] + 432.52 mV. It was potentially applied for the quantification of CTB in its commercial injections and spiked serum samples with mean recoveries % 99.85 ± 0.3, 99.87 ± 0.4 and 99.78 ± 0.4 %, respectively. The outcomes were compared with those obtained from various addressed analytical techniques and showed high selectivity and sensitivity for CTB determination rather than other reported analytical techniques. The rationality of the demonstrated potentiometric probe was ensured and assessed with respect to international conference harmonization recommendations. The outcomes proved that the method was accurate and precise for the determination of the investigated drug.