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Prospects of IL-2 in Cancer Immunotherapy
Journal article   Open access  Peer reviewed

Prospects of IL-2 in Cancer Immunotherapy

Hani Choudhry, Nawal Helmi, Wesam H Abdulaal, Mustafa Zeyadi, Mazin A Zamzami, Wei Wu, Maged Mostafa Mahmoud, Mohiuddin Khan Warsi, Mahmood Rasool and Mohammad S Jamal
BioMed research international, Vol.2018, pp.9056173-7
01/01/2018
DOI: https://doi.org/10.1155/2018/9056173
PMCID: PMC5960517
PMID: 29854806

Abstract

Animals Dose-Response Relationship, Immunologic Humans Immunotherapy Interleukin-2 - metabolism Models, Biological Neoplasms - immunology Neoplasms - therapy Signal Transduction
IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.
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https://doi.org/10.1155/2018/9056173View
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