Abstract
Trigonella hamosa saponins (SS) were purified using Sephadex LH-20. The effects of SS on diabetes, lipid profiles and glucose homeostasis were investigated by supplementation of the diet of rats with SS, which countered the adverse, harmful effects of chronic diabetes by improving insulin synthesis, secretion and action, enhancing lipid and protein metabolism, and removing the oxidative stress concomitant with glucose homeostasis.