Abstract
The present study was performed to investigate the protective effect of black rice ethanolic extract (BREE) on liver injury induced by ethyl alcohol in male rats: The study was conducted on 40 male Wistar rats weighing (190-200 g), The animals were divided into 4 equal groups. The first group, was received:basal diet and used as a normal: control. group (NC). The second group were administered ethyl alcohol (6 g/kg bw) orally and used as positive control (PC). The other groups of rats were administered ethyl,alcohol (6 mg/kg bw) + BREE (125 and 250. mg/kg bw/day). Blood and tissue samples were collected after 2 weeks. The results revealed that the rats treated with ethyl alcohol. showed a significant (p <= 0.05) increae in. levels of TC, TL, TG, ALT and AST. Ethyl alcohol. intoxication induces "some pathological alteratfons in the liver as degeneration of cytoplasm and nuclei manifest clear symptoms of pyknosis and karyOrrhexis. The rise in serum hepatic enzymes, TC, TL, TG, histopathological and immunohistochemical changes were significantly attenuated by BREE. The current results clearly investigate the beneficial effects, of BREE in controlling ethyl, alcohol disorders induced and the protection of liver againSt ethyl alcohol intoxication..