Abstract
The present work was designed to evaluate the protective role of lycopene against renal histopathological changes due to arsenic toxicity. The animals were divided into four groups with six in each: Group I: served as control animals received saline, Group II: receive lycopene (5 mg/kg b.w). Group III: received once daily sodium arsenite at a dose of 5 mg/kg b.w. Group IV: receive once daily sodium arsenite plus lycopene. Histological examinations revealed that sodium arsenate caused glomeruli hypercellularity, disappearance of Bowman's capsule, lymphocytic infiltrations, interstitial hemorrhages among the renal tubules. Sodium arsenate treated animals showed positive reaction to Bax in renal tubules as compared with controls. Co-administration with lycopene decrease and improve pathological changes in the kidney.