Abstract
The present study was designed to evaluate the potential protective role of the aqueous extract of rosemary (Rosmarinus officinalis) (AER) against trichloro acetate (TCA) induced renal-toxicity in male albino rats. 40 male albino rats were divided into 4 groups of ten: group A served as control; group B was given AER (200 mg/kg/day) by gavage; group C received TCA at the dose 50 mg/kg/day and group D was treated with AER (200 mg/kg/day) and received TCA (50 mg/kg/day). The experiment was carried out for two months. The toxicity of TCA for rats was revealed by an increase in kidney biomarkers [urea, ceratenin and uric acid]. The TCA treatment caused a significant increase in MDA (malondialdehyde) level and the activities of CAT (catalase), SOD (superoxide dismutase) and GPx (glutathione peroxidase) in kidney tissues. These biochemical effects were accompanied by histological indicators of kidney damage. Treatment with AER recovered the kidney toxicity (induced by TCA treatment), as demonstrated by perfection of kidney biomarkers; as well as antioxidant parameters (CAT, SOD, GPx and MDA) and amelioration of histopathology changes in kidney tissues. It could be concluded that AER supplementation for 2 months in TCA induced toxicity in rats benefited renal antioxidant status and improved kidney injury and damage in male albino rats exposed to TCA.