Abstract
The present protocol describes the synthesis of di and tri-substituted s-triazine derivatives•s-Triazine undergoes sequential nucleophilic substitution reaction but order of nucleophile is very crucial.•It is very difficult to substitute any nucleophile except amine once amine is incorporated onto s-triazine.•During the synthesis of O,N-type substituted s-triazine, always O-type should be incorporated first.
[Display omitted]