Abstract
Porencephaly is a rare congenital disorder of the central nervous system involving a cyst or a cavity filled with cerebrospinal fluid in brain's parenchyma. Prefrontal cortical dysfunction is often associated with development of psychotic symptoms. We present a case of a 26-year-old female with first episode of psychosis who was found to be suffering from porencephaly of left frontal cortex. There are only a few case reports of porencephaly associated with psychosis in literature. Porencephaly may contribute to the development of psychosis, especially if located in the frontal lobe of brain.