Abstract
This study was aimed to evaluate the hypoglycaemic, hypolipidemic and liver protective effects of pumpkin and sunflower seeds powder in male diabetic rats. A total of 24 rats were randomized into 4 groups of 6 each as follows: Group 1: Normal control; Group 2: Diabetic control; Group 3: Diabetics administered with pumpkin seeds powder (3%); Group 4: Diabetics administered with sunflower seeds powder (3%). The rats were made diabetic by alloxan (100 body weight (BW)) injection and were treated until blood glucose mg/kg g/kg reach to above 200 mg/dl. Blood samples were collected following the experiment. Liver specimens were al so collected for histological analysis. Glucose, cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ALT activity, AST activity were significantly increased, while total protein and albumin were decreased in diabetic rats as compared to the normal control group. Pumpkin and sunflower seeds significantly decreased glucose, cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ALT activity, AST activity as compared to diabetic group. Therefore, pumpkin and sunflower seeds might be beneficial in diabetic patients.