Abstract
In this study, nitrogen-nitrogen bonds containing compounds such as hydrazine derivatives are examined. There are relatively few hydrazine molecules in nature, but some have been isolated from plants, marine organisms and microorganisms. Thus, hydrazine molecules are widely used in the manufacture of synthetic catalysts, agriculture chemicals, pesticides, and also cause irreversible pollution to air, water, and soil. Hydrazine compounds were evaluated via larvicidal profile in a stagnant water system. According to the above observation, new 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derivatives can be synthesized via catalyst free green chemistry approach.A range of FT-IR spectroscopic measures, 1H and 13C NMR, as well as mass spectra, were used to characterize the compounds (2a-e). The compound 2e was more potent (95,6% mortality, LD50: 20.1 µg/ mL) against Culex quinquefasciatus than natural pyrazolidine derivatives. Therefore, the objective of this study, prospered with a few of the pyrzolopyridine hydrazine models, which are demonstrated to be low toxic environmentally safe and high potential larvicidal profile.