Abstract
Pyridazinopyrazolotriazine
A general method for the preparation of substituted pyridazinopyrazolotriazines is reported. 3-Aminopyrazolo[3,4-
d]pyridazine was diazotized and coupled with active methylene reagents to afford the tricyclic pyridazino[3′,4′:3,4]pyrazolo[5,1-
c]-1,2,4-triazines with substituents such as methyl, phenyl, ethoxycarbonyl, acetyl or benzoyl, depending on the methylene reagent used. In addition several condensation reactions with hydrazines gave the corresponding acid hydrazide and/or hydrazones. Reactions of
3 with aromatic aldehydes afforded hydrazones. The products were screened for their antimicrobial activity against five microorganisms.