Abstract
Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for the generation of library of enormous lead molecules. Owing to its vast pharmacological profile, pyrrole and its analogues have drawn much attention of the researchers/chemists round the globe to be explored exhaustively for the benefit of mankind. This review focusses on recent advancements; pertaining to pyrrole scaffold, discussing various aspects of structure activity relationship and its bioactivities.
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•Pyrrole is a heterocyclic aromatic five membered multiple pharmacophoric template.•The name pyrrole came from the Greek word ‘pyrrols’ means fiery from the reaction.•Pyrroles exhibit lower basicity due to delocalization of lone pair of electrons of nitrogen atom in the pyrrole ring.•The NH and CH protons are moderately acidic and can be deprotonated with strong bases, showing its nucleophilic nature.