Abstract
A QSPR treatment has been applied to a data set consisting of 60 3-aryloxazolidin-2-one antibacterials to relate the in vitro minimum inhibitory concentration (MIC) (required for inhibiting growth of
Staphylococcuc aureus) with theoretical molecular and fragment descriptors. The treatment using
codessa pro descriptors leads to a seven-parameter model with
r
2=0.820 and
r
2
cv=0.758.
A QSPR treatment has been applied to a data set consisting of 60 3-aryloxazolidin-2-one antibacterials to relate the in vitro minimum inhibitory concentration (MIC) (required to inhibiting growth of
S. aureus) with theoretical molecular and fragment descriptors. The treatment using
codessa pro descriptors leads to a seven-parameter model with
r
2=0.820 and
r
2
cv=0.758.