Abstract
Paracetamol (acetaminophen) (PA) is a widely used as an analgesic and antipyretic drug that is commonly available in without a prescription. Paracetamol has been used to treat many diseases such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It cures pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joints. It has been reported as the common cause of drug toxic ingestion. These studies aim to compare the effect of some Paracetamol derivatives such Phenacetin, p-nitroacetanilide, p-bromoacetanilide and n-acetylanthranilic acid on liver structure to avoid Paracetamol cancer effect during its metabolism. From the histological point of view, it has been found that p-nitroacetanilide is the best alternative due to its metabolite products.