Abstract
A duloxetine ion selective membrane electrode is prepared. The electrode incorporates PVC membrane with duloxetine-silicomolybdate (DLX-SMA) ion pair complex with dioctylphthalate (DOP) as a plasticizer. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide duloxetine concentration range (1.0×10-5 to 1.0×10-2 M) with a slope of 59.40 mV dec-1 of concentration, a wide working pH range (4.3–8.4) and a fast response time (< 15 s). The electrode showed good selectivity towards duloxetine with respect to some metal ions, sugars and amino acids. The electrode has been applied to the determination of duloxetine hydrochloride in different pharmaceutical preparations and in urine.