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Quinine bis-conjugates with quinolone antibiotics and peptides: synthesis and antimalarial bioassay
Journal article   Peer reviewed

Quinine bis-conjugates with quinolone antibiotics and peptides: synthesis and antimalarial bioassay

Siva S. Panda, Kiran Bajaj, Marvin J. Meyers, Francis M. Sverdrup and Alan R. Katritzky
Organic & biomolecular chemistry, Vol.10(45), pp.8985-8993
07/12/2012
DOI: https://doi.org/10.1039/c2ob26439k
PMID: 23070233

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Benzotriazole-mediated syntheses led to novel bis-conjugates of quinine with quinolone antibiotics and amino acid linkers which were successfully prepared by two alternative routes with excellent yields and retention of chirality. These bis conjugates retain in vitro antimalarial activity with IC50 values ranging from 12 to 207 nM, similar to quinine itself.

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