Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

Myrna G. Serrano; Hardik I. Parikh; J. Paul Brooks; David J. Edwards; Tom J. Arodz; Laahirie Edupuganti; Bernice Huang; Philippe H. Girerd; Yahya A. Bokhari; Steven P. Bradley; Jamie L. Brooks; Molly R. Dickinson; Jennifer I. Drake; Robert A. Duckworth; Stephen S. Fong; Abigail L. Glascock; Sophonie Jean; Nicole R. Jimenez; Joseph Khoury; Vishal N. Koparde; Ana M. Lara; Vladimir Lee; Andrey V. Matveyev; Sarah H. Milton; Shreni D. Mistry; Sarah K. Rozycki; Nihar U. Sheth; Ekaterina Smirnova; Stephany C. Vivadelli; N. Romesh Wijesooriya; Jie Xu; Ping Xu; Donald O. Chaffin; Amber L. Sexton; Michael G. Gravett; Craig E. Rubens; Karen D. Hendricks-Munoz; Kimberly K. Jefferson; Jerome F. Strauss; Jennifer M. Fettweis; Gregory A. Buck

doi:10.1038/s41591-019-0465-8

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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

Journal article

Peer reviewed

Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

Myrna G. Serrano, Hardik I. Parikh, J. Paul Brooks, David J. Edwards, Tom J. Arodz, Laahirie Edupuganti, Bernice Huang, Philippe H. Girerd, Yahya A. Bokhari, Steven P. Bradley, …

Nature medicine, Vol.25(6), pp.1001-1011

01/06/2019

DOI: https://doi.org/10.1038/s41591-019-0465-8

PMCID: PMC6746180

PMID: 31142850

Abstract

Biochemistry & Molecular Biology

Cell Biology

Life Sciences & Biomedicine

Medicine, Research & Experimental

Research & Experimental Medicine

Science & Technology

The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

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Title: Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy
Creators - without role: Myrna G. Serrano - Virginia Commonwealth University
Hardik I. Parikh - Virginia Commonwealth University
J. Paul Brooks - Virginia Commonwealth University
David J. Edwards - Virginia Commonwealth University
Tom J. Arodz - Virginia Commonwealth University
Laahirie Edupuganti - Virginia Commonwealth University
Bernice Huang - Virginia Commonwealth University
Philippe H. Girerd - Virginia Commonwealth University
Yahya A. Bokhari - Virginia Commonwealth University
Steven P. Bradley - Virginia Commonwealth University
Jamie L. Brooks - Virginia Commonwealth University
Molly R. Dickinson - Virginia Commonwealth University
Jennifer I. Drake - Virginia Commonwealth University
Robert A. Duckworth - Virginia Commonwealth University
Stephen S. Fong - Virginia Commonwealth University
Abigail L. Glascock - Virginia Commonwealth University
Sophonie Jean - Virginia Commonwealth University
Nicole R. Jimenez - Virginia Commonwealth University
Joseph Khoury - Children's Hospital of Richmond at VCU
Vishal N. Koparde - Virginia Commonwealth University
Ana M. Lara - Virginia Commonwealth University
Vladimir Lee - Virginia Commonwealth University
Andrey V. Matveyev - Virginia Commonwealth University
Sarah H. Milton - Virginia Commonwealth University
Shreni D. Mistry - Virginia Commonwealth University
Sarah K. Rozycki - Virginia Commonwealth University
Nihar U. Sheth - Virginia Commonwealth University
Ekaterina Smirnova - Virginia Commonwealth University
Stephany C. Vivadelli - Virginia Commonwealth University
N. Romesh Wijesooriya - Children's Hospital of Richmond at VCU
Jie Xu - Children's Hospital of Richmond at VCU
Ping Xu - Virginia Commonwealth University
Donald O. Chaffin - Global Alliance to Prevent Prematurity and Stillbirth
Amber L. Sexton - Global Alliance to Prevent Prematurity and Stillbirth
Michael G. Gravett - Global Alliance to Prevent Prematurity and Stillbirth
Craig E. Rubens - Global Alliance to Prevent Prematurity and Stillbirth
Karen D. Hendricks-Munoz - Children's Hospital of Richmond at VCU
Kimberly K. Jefferson - Virginia Commonwealth University
Jerome F. Strauss - Virginia Commonwealth University
Jennifer M. Fettweis - Virginia Commonwealth University
Gregory A. Buck - Virginia Commonwealth University
Publication Details: Nature medicine, Vol.25(6), pp.1001-1011
Publisher: NATURE PORTFOLIO
Number of pages: 25
Grant note: GAPPS BMGF PPB grant National Center for Complementary and Integrative Health R01HD092415; R21HD092965 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) National Institute of Allergy and Infectious Disease at NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Common Fund UH3AI083263; U54HD080784; R21HD092965; 1R01HD092415 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R25GM090084 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Eunice Kenedy Shriver National Institute of Child Heatlh and Human Development Office of Research on Women's Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Office of Research on Women's Health (ORWH)
Identifiers: 9921265408331
Academic Unit: King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article