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Radiochemical F-18-fluoroarylation of unsaturated alpha-, beta- and gamma-amino acids, application to a radiolabelled analogue of baclofen
Journal article   Peer reviewed

Radiochemical F-18-fluoroarylation of unsaturated alpha-, beta- and gamma-amino acids, application to a radiolabelled analogue of baclofen

Sarah B. Hoefling, Christina Hultsch, Hans-Juergen Wester and Markus R. Heinrich
Tetrahedron, Vol.64(52), pp.11846-11851
22/12/2008
DOI: https://doi.org/10.1016/j.tet.2008.07.117

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Unsaturated alpha-, beta- and gamma-amino acids have been investigated as substrates for the reductive Meerwein arylation. Radical reactions of this type have been shown to be a valuable tool for the fast and efficient introduction of the 4-[F-18]fluorophenyl group into precursor molecules allowing short-time syntheses of potential PET radiotracers, which would be more difficult to access by other methods. (C) 2008 Elsevier Ltd. All rights reserved.

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