Abstract
Hepatitis C virus (HCV) is a lymphotropic virus that triggers B-cells and fosters favorable conditions for B lymphocyte growth. As a result, the virus has been linked to a number of lymphoproliferative diseases, including mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma. Our case was a 25-year-old man known case of HCV infection presented with history of jaundice. Computed tomography (CT) of the abdomen and pelvis revealed two large hypodense lesions involving both lobes of the liver. On whole-body positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with CT (18F-FDG PET/CT), the lesions appear as two large heterogeneous FDG-avid hypodense hepatic lesions. The pathology report confirms the diagnosis of primary hepatic diffuse large B-cell non-Hodgkin's lymphoma with Ki-67 of 90%. This case illustrates the imaging findings of this rare hepatic lesion and the importance of using 18F-FDG PET/CT scan in the follow-up of liver lesions.