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Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ)
Journal article   Open access  Peer reviewed

Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ)

Rickdeb Sen, Jorge Escorihuela, Floris van Delft and Han Zuilhof
Angewandte Chemie (International ed.), Vol.56(12), pp.3299-3303
13/03/2017
DOI: https://doi.org/10.1002/anie.201612037
PMCID: PMC5363232
PMID: 28198134

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non-4-yne (BCN) and surface-bound quinones revealed an unprecedented 100% conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART-MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.
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https://doi.org/10.1002/anie.201612037View
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