Abstract
The study is intended to monitor the comparative degradation rates of acetaminophen in binary and ternary combinations by UV–vis spectroscopy. The drugs were exposed to UV-rays in blister packing. The exposition time was 24, 48 and 72h for both shorter and longer wavelengths. The problem of overlapping UV bands of aspirin and caffeine with acetaminophen was solved by extracting them in diethylether, therefore, we developed a straightforward, rapid and accurate assay method for measuring acetaminophen concentration in binary and ternary mixtures and to monitor its degradation.