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Rapid cesium fluoride-catalyzed Knoevenagel condensation for the synthesis of highly functionalized 4,4'-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives
Journal article   Peer reviewed

Rapid cesium fluoride-catalyzed Knoevenagel condensation for the synthesis of highly functionalized 4,4'-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives

Khalid Mohammed Khan, Munira Taj Muhammad, Imran Khan, Shahnaz Perveen and Wolfgang Voelter
Monatshefte für Chemie, Vol.146(9), pp.1587-1590
01/09/2015
DOI: https://doi.org/10.1007/s00706-015-1424-9

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A rapid, convenient, and environmentally friendly protocol was developed for the synthesis of functionalized 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) via a tandem Knoevenagel-Michael reaction by condensing pyrazolone with readily available differently substituted aldehydes and catalyzed by cesium fluoride at room temperature.

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