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Rapid synthesis of 2 ',3 '-dideoxy-3 'beta-fluoro-pyrimidine nucleosides from 2 '-deoxypyrimidine nucleosides
Journal article   Peer reviewed

Rapid synthesis of 2 ',3 '-dideoxy-3 'beta-fluoro-pyrimidine nucleosides from 2 '-deoxypyrimidine nucleosides

Ahmed Khalil, Christophe Mathe and Christian Perigaud
Bioorganic chemistry, Vol.38(4-6), pp.271-274
12/2010
DOI: https://doi.org/10.1016/j.bioorg.2010.08.003
PMID: 20869741

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Organic Life Sciences & Biomedicine Physical Sciences Science & Technology
A rapid synthesis of 2',3'-dideoxy-3'-fluoro-beta-D-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral drugs. However, when evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity. (C) 2010 Elsevier Inc. All rights reserved.

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