Rare and low-frequency coding variants alter human adult height

Eirini Marouli; Mariaelisa Graff; Carolina Medina-Gomez; Ken Sin Lo; Andrew R. Wood; Troels R. Kjaer; Rebecca S. Fine; Yingchang Lu; Claudia Schurmann; Heather M. Highland; Sina Rueger; Gudmar Thorleifsson; Anne E. Justice; David Lamparter; Kathleen E. Stirrups; Valerie Turcot; Kristin L. Young; Thomas W. Winkler; Tonu Esko; Tugce Karaderi; Adam E. Locke; Nicholas G. D. Masca; Maggie C. Y. Ng; Poorva Mudgal; Manuel A. Rivas; Sailaja Vedantam; Anubha Mahajan; Xiuqing Guo; Goncalo Abecasis; Katja K. Aben; Linda S. Adair; Dewan S. Alam; Eva Albrecht; Kristine H. Allin; Matthew Allison; Philippe Amouyel; Emil V. Appel; Dominique Arveiler; Folkert W. Asselbergs; Paul L. Auer; Beverley Balkau; Bernhard Banas; Lia E. Bang; Marianne Benn; Sven Bergmann; Lawrence F. Bielak; Matthias Blueher; Heiner Boeing; Eric Boerwinkle; Carsten A. Boeger; Lori L. Bonnycastle; Jette Bork-Jensen; Michiel L. Bots; Erwin P. Bottinger; Donald W. Bowden; Ivan Brandslund; Gerome Breen; Murray H. Brilliant; Linda Broer; Amber A. Burt; Adam S. Butterworth; David J. Carey; Mark J. Caulfield; John C. Chambers; Daniel I. Chasman; Yii-Der Ida Chen; Rajiv Chowdhury; Cramer Christensen; Audrey Y. Chu; Massimiliano Cocca; Francis S. Collins; James P. Cook; Janie Corley; Jordi Corominas Galbany; Amanda J. Cox; Gabriel Cuellar-Partida; John Danesh; Gail Davies; Paul I. W. de Bakker; Gert J. de Borst; Simon de Denus; Mark C. H. de Groot; Renee de Mutsert; Ian J. Deary; George Dedoussis; Ellen W. Demerath; Anneke I. den Hollander; Joe G. Dennis; Emanuele Di Angelantonio; Fotios Drenos; Mengmeng Du; Alison M. Dunning; Douglas F. Easton; Tapani Ebeling; Todd L. Edwards; Patrick T. Ellinor; Paul Elliott; Evangelos Evangelou; Aliki-Eleni Farmaki; Jessica D. Faul; Mary F. Feitosa; Shuang Feng; Ele Ferrannini; Marco M. Ferrario; Jean Ferrieres; Jose C. Florez; Ian Ford; Myriam Fornage; Paul W. Franks; Ruth Frikke-Schmidt; Tessel E. Galesloot; Wei Gan; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Ayush Giri; Giorgia Girotto; Scott D. Gordon; Penny Gordon-Larsen; Mathias Gorski; Niels Grarup; Megan L. Grove; Vilmundur Gudnason; Stefan Gustafsson; Torben Hansen; Kathleen Mullan Harris; Tamara B. Harris; Andrew T. Hattersley; Caroline Hayward; Liang He; Iris M. Heid; Kauko Heikkila; Oyvind Helgeland; Jussi Hernesniemi; Alex W. Hewitt; Lynne J. Hocking; Mette Hollensted; Oddgeir L. Holmen; G. Kees Hovingh; Joanna M. M. Howson; Carel B. Hoyng; Paul L. Huang; Kristian Hveem; M. Arfan Ikram; Erik Ingelsson; Anne U. Jackson; Jan-Hakan Jansson; Gail P. Jarvik; Gorm B. Jensen; Min A. Jhun; Yucheng Jia; Xuejuan Jiang; Stefan Johansson; Marit E. Jorgensen; Torben Jorgensen; Pekka Jousilahti; J. Wouter Jukema; Bratati Kahali; Rene S. Kahn; Mika Kahonen; Pia R. Kamstrup; Stavroula Kanoni; Jaakko Kaprio; Maria Karaleftheri; Sharon L. R. Kardia; Fredrik Karpe; Frank Kee; Renske Keeman; Lambertus A. Kiemeney; Hidetoshi Kitajima; Kirsten B. Kluivers; Thomas Kocher; Pirjo Komulainen; Jukka Kontto; Jaspal S. Kooner; Charles Kooperberg; Peter Kovacs; Jennifer Kriebel; Helena Kuivaniemi; Sebastien Kury; Johanna Kuusisto; Martina La Bianca; Markku Laakso; Timo A. Lakka; Ethan M. Lange; Leslie A. Lange; Carl D. Langefeld; Claudia Langenberg; Eric B. Larson; I-Te Lee; Terho Lehtimaki; Cora E. Lewis; Huaixing Li; Jin Li; Ruifang Li-Gao; Honghuang Lin; Li-An Lin; Xu Lin; Lars Lind; Jaana Lindstrom; Allan Linneberg; Yeheng Liu; Yongmei Liu; Artitaya Lophatananon; Jian'an Luan; Steven A. Lubitz; Leo-Pekka Lyytikainen; David A. Mackey; Pamela A. F. Madden; Alisa K. Manning; Satu Mannisto; Gaelle Marenne; Jonathan Marten; Nicholas G. Martin; Angela L. Mazul; Karina Meidtner; Andres Metspalu; Paul Mitchell; Karen L. Mohlke; Dennis O. Mook-Kanamori; Anna Morgan; Andrew D. Morris; Andrew P. Morris; Martina Mueller-Nurasyid; Patricia B. Munroe; Mike A. Nalls; Matthias Nauck; Christopher P. Nelson; Matt Neville; Sune F. Nielsen; Kjell Nikus; Pal R. Njolstad; Borge G. Nordestgaard; Ioanna Ntalla; Jeffrey R. O'Connel; Heikki Oksa; Loes M. Olde Loohuis; Roel A. Ophoff; Katharine R. Owen; Chris J. Packard; Sandosh Padmanabhan; Colin N. A. Palmer; Gerard Pasterkamp; Aniruddh P. Patel; Alison Pattie; Oluf Pedersen; Peggy L. Peissig; Gina M. Peloso; Craig E. Pennell; Markus Perola; James A. Perry; John R. B. Perry; Thomas N. Person; Ailith Pirie; Ozren Polasek; Danielle Posthuma; Olli T. Raitakari; Asif Rasheed; Rainer Rauramaa; Dermot F. Reilly; Alex P. Reiner; Frida Renstrom; Paul M. Ridker; John D. Rioux; Neil Robertson; Antonietta Robino; Olov Rolandsson; Igor Rudan; Katherine S. Ruth; Danish Saleheen; Veikko Salomaa; Nilesh J. Samani; Kevin Sandow; Yadav Sapkota; Naveed Sattar; Marjanka K. Schmidt; Pamela J. Schreiner; Matthias B. Schulze; Robert A. Scott; Marcelo P. Segura-Lepe; Svati Shah; Xueling Sim; Suthesh Sivapalaratnam; Kerrin S. Small; Albert Vernon Smith; Jennifer A. Smith; Lorraine Southam; Timothy D. Spector; Elizabeth K. Speliotes; John M. Starr; Valgerdur Steinthorsdottir; Heather M. Stringham; Michael Stumvoll; Praveen Surendran; Leen M. 't Hart; Katherine E. Tansey; Jean-Claude Tardif; Kent D. Taylor; Alexander Teumer; Deborah J. Thompson; Unnur Thorsteinsdottir; Betina H. Thuesen; Anke Toenjes; Gerard Tromp; Stella Trompet; Emmanouil Tsafantakis; Jaakko Tuomilehto; Anne Tybjaerg-Hansen; Jonathan P. Tyrer; Rudolf Uher; Andre G. Uitterlinden; Sheila Ulivi; Sander W. van der Laan; Andries R. Van Der Leij; Cornelia M. van Duijn; Natasja M. van Schoor; Jessica van Setten; Anette Varbo; Tibor V. Varga; Rohit Varma; Digna R. Velez Edwards; Sita H. Vermeulen; Henrik Vestergaard; Veronique Vitart; Thomas F. Vogt; Diego Vozzi; Mark Walker; Feijie Wang; Carol A. Wang; Shuai Wang; Yiqin Wang; Nicholas J. Wareham; Helen R. Warren; Jennifer Wessel; Sara M. Willems; James G. Wilson; Daniel R. Witte; Michael O. Woods; Ying Wu; Hanieh Yaghootkar; Jie Yao; Pang Yao; Laura M. Yerges-Armstrong; Robin Young; Eleftheria Zeggini; Xiaowei Zhan; Weihua Zhang; Jing Hua Zhao; Wei Zhao; He Zheng; Wei Zhou; Jerome I. Rotter; Michael Boehnke; Sekar Kathiresan; Mark I. McCarthy; Cristen J. Willer; Kari Stefansson; Ingrid B. Borecki; Dajiang J. Liu; Kari E. North; Nancy L. Heard-Costa; Tune H. Pers; Cecilia M. Lindgren; Claus Oxvig; Zoltan Kutalik; Fernando Rivadeneira; Ruth J. F. Loos; Timothy M. Frayling; Joel N. Hirschhorn; Panos Deloukas; Guillaume Lettre; EPIC-CVD Consortium

doi:10.1038/nature21039

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Rare and low-frequency coding variants alter human adult height

Journal article

Peer reviewed

Rare and low-frequency coding variants alter human adult height

Eirini Marouli, Mariaelisa Graff, Carolina Medina-Gomez, Ken Sin Lo, Andrew R. Wood, Troels R. Kjaer, Rebecca S. Fine, Yingchang Lu, Claudia Schurmann, Heather M. Highland, …

Nature (London), Vol.542(7640), pp.186-190

09/02/2017

DOI: https://doi.org/10.1038/nature21039

PMCID: PMC5302847

PMID: 28146470

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.

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Title: Rare and low-frequency coding variants alter human adult height
Creators - without role: Eirini Marouli - Queen Mary University of London
Mariaelisa Graff - University of North Carolina at Chapel Hill
Carolina Medina-Gomez - Erasmus MC
Ken Sin Lo - Montreal Heart Institute
Andrew R. Wood - University of Exeter
Troels R. Kjaer - Aarhus University
Rebecca S. Fine - Broad Institute
Yingchang Lu - Icahn School of Medicine at Mount Sinai
Claudia Schurmann - Icahn School of Medicine at Mount Sinai
Heather M. Highland - University of North Carolina at Chapel Hill
Sina Rueger - Institute of Social and Preventive Medicine
Gudmar Thorleifsson - deCODE Genetics
Anne E. Justice - University of North Carolina at Chapel Hill
David Lamparter - SIB Swiss Institute of Bioinformatics
Kathleen E. Stirrups - University of Cambridge
Valerie Turcot - Montreal Heart Institute
Kristin L. Young - University of North Carolina at Chapel Hill
Thomas W. Winkler - University of Regensburg
Tonu Esko - University of Tartu
Tugce Karaderi - Wellcome Centre for Human Genetics
Adam E. Locke - James S. McDonnell Foundation
Nicholas G. D. Masca - Glenfield Hospital
Maggie C. Y. Ng - Supreme Council Of Health
Poorva Mudgal - Wake Forest University
Manuel A. Rivas - Broad Institute
Sailaja Vedantam - Boston Children's Hospital
Anubha Mahajan - Wellcome Centre for Human Genetics
Xiuqing Guo - The Lundquist Institute
Goncalo Abecasis - Statistical Research
Katja K. Aben - Netherlands Comprehensive Cancer Organisation
Linda S. Adair - University of North Carolina at Chapel Hill
Dewan S. Alam - Ctr Control Chron Dis, Dhaka 1212, Bangladesh
Eva Albrecht - Helmholtz Zentrum München
Kristine H. Allin - University of Copenhagen
Matthew Allison - University of California, San Diego
Philippe Amouyel - Inserm
Emil V. Appel - University of Copenhagen
Dominique Arveiler - University of Strasbourg
Folkert W. Asselbergs - University Medical Center Utrecht
Paul L. Auer - University of Wisconsin–Milwaukee
Beverley Balkau - Centre de recherche en Epidémiologie et Santé des Populations
Bernhard Banas - University Hospital Regensburg
Lia E. Bang - Copenhagen University Hospital
Marianne Benn - Gentofte Hospital
Sven Bergmann - SIB Swiss Institute of Bioinformatics
Lawrence F. Bielak - University of Michigan–Ann Arbor
Matthias Blueher - College Station Medical Center
Heiner Boeing - German Institute of Human Nutrition
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Carsten A. Boeger - Univ Hosp Regensburg, Dept Nephrol, D-93042 Regensburg, Germany
Lori L. Bonnycastle - National Institutes of Health
Jette Bork-Jensen - Novo Nordisk Foundation
Michiel L. Bots - University Medical Center Utrecht
Erwin P. Bottinger - Icahn School of Medicine at Mount Sinai
Donald W. Bowden - Wake Forest University
Ivan Brandslund - Lillebaelt Hospital
Gerome Breen - King's College London
Murray H. Brilliant - Marshfield Clinic
Linda Broer - Erasmus MC
Amber A. Burt - University of Washington
Adam S. Butterworth - University of Cambridge
David J. Carey - Sigfried & Janet Weis Ctr Res, Danville, PA 17822 USA
Mark J. Caulfield - Queen Mary University of London
John C. Chambers - Imperial College London
Daniel I. Chasman - Broad Institute
Yii-Der Ida Chen - Harbor–UCLA Medical Center
Rajiv Chowdhury - University of Cambridge
Cramer Christensen - Lillebaelt Hospital
Audrey Y. Chu - Brigham and Women's Hospital
Massimiliano Cocca - University of Trieste
Francis S. Collins - National Institutes of Health
James P. Cook - University of Liverpool
Janie Corley - University of Edinburgh
Jordi Corominas Galbany - Radboud University Nijmegen
Amanda J. Cox - Wake Forest University
Gabriel Cuellar-Partida - QIMR Berghofer Medical Research Institute
John Danesh - Wellcome Sanger Institute
Gail Davies - University of Edinburgh
Paul I. W. de Bakker - University Medical Center Utrecht
Gert J. de Borst - University Medical Center Utrecht
Simon de Denus - Montreal Heart Institute
Mark C. H. de Groot - College Station Medical Center
Renee de Mutsert - Leiden University Medical Center
Ian J. Deary - University of Edinburgh
George Dedoussis - Harokopio University of Athens
Ellen W. Demerath - University of Minnesota
Anneke I. den Hollander - College Station Medical Center
Joe G. Dennis - University of Cambridge
Emanuele Di Angelantonio - University of Cambridge
Fotios Drenos - University College London
Mengmeng Du - Fred Hutch Cancer Center
Alison M. Dunning - University of Cambridge
Douglas F. Easton - University of Cambridge
Tapani Ebeling - Oulu University Hospital
Todd L. Edwards - Vanderbilt University
Patrick T. Ellinor - Broad Institute
Paul Elliott - Imperial College London
Evangelos Evangelou - Imperial College London
Aliki-Eleni Farmaki - Harokopio University of Athens
Jessica D. Faul - University of Michigan–Ann Arbor
Mary F. Feitosa - Supreme Council Of Health
Shuang Feng - Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Ele Ferrannini - CNR Inst Clin Physiol, Pisa, Italy
Marco M. Ferrario - University of Insubria
Jean Ferrieres - Supreme Council Of Health
Jose C. Florez - Massachusetts Gen Hosp, Boston, MA 02114 USA
Ian Ford - University of Glasgow
Myriam Fornage - College Station Medical Center
Paul W. Franks - Lund University
Ruth Frikke-Schmidt - University of Copenhagen
Tessel E. Galesloot - Radboud University Nijmegen
Wei Gan - University of Oxford
Ilaria Gandin - University of Trieste
Paolo Gasparini - University of Trieste
Vilmantas Giedraitis - Uppsala University
Ayush Giri - Vanderbilt University
Giorgia Girotto - University of Trieste
Scott D. Gordon - College Station Medical Center
Penny Gordon-Larsen - Univ N Carolina, Caroline Populat Ctr, Chapel Hill, NC 27514 USA
Mathias Gorski - University of Regensburg
Niels Grarup - University of Copenhagen
Megan L. Grove - Supreme Council Of Health
Vilmundur Gudnason - University of Iceland
Stefan Gustafsson - Uppsala University
Torben Hansen - University of Copenhagen
Kathleen Mullan Harris - Univ N Carolina, Caroline Populat Ctr, Chapel Hill, NC 27514 USA
Tamara B. Harris - NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA
Andrew T. Hattersley - University of Exeter
Caroline Hayward - University of Edinburgh
Liang He - Duke University
Iris M. Heid - University of Regensburg
Kauko Heikkila - University of Helsinki
Oyvind Helgeland - Haukeland Hosp, Dept Pediat, N-5021 Bergen, Norway
Jussi Hernesniemi - Tampere University
Alex W. Hewitt - University of Melbourne
Lynne J. Hocking - University of Edinburgh
Mette Hollensted - University of Copenhagen
Oddgeir L. Holmen - Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth, KG Jebsen Ctr Genet Epidemiol, N-7600 Trondheim, Norway
G. Kees Hovingh - Asan Medical Center
Joanna M. M. Howson - University of Cambridge
Carel B. Hoyng - College Station Medical Center
Paul L. Huang - Massachusetts Gen Hosp, Boston, MA 02114 USA
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, N-7600 Levanger, Norway
M. Arfan Ikram - Supreme Council Of Health
Erik Ingelsson - Uppsala University
Anne U. Jackson - Biostat
Jan-Hakan Jansson - Umeå University
Gail P. Jarvik - University of Washington
Gorm B. Jensen - Frederiksberg Univ Hosp, Copenhagen City Heart Study, DK-2000 Frederiksberg, Denmark
Min A. Jhun - Supreme Council Of Health
Yucheng Jia - College Station Medical Center
Xuejuan Jiang - Supreme Council Of Health
Stefan Johansson - University of Bergen
Marit E. Jorgensen - University of Southern Denmark
Torben Jorgensen - University of Copenhagen
Pekka Jousilahti - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
J. Wouter Jukema - Leiden University
Bratati Kahali - College Station Medical Center
Rene S. Kahn - College Station Medical Center
Mika Kahonen - University of Tampere
Pia R. Kamstrup - Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark
Stavroula Kanoni - Queen Mary University of London
Jaakko Kaprio - University of Helsinki
Maria Karaleftheri - College Station Medical Center
Sharon L. R. Kardia - Supreme Council Of Health
Fredrik Karpe - University of Oxford
Frank Kee - Queens University
Renske Keeman - Netherlands Canc Inst, Antoni van Leewenhoek Hosp, NL-1066 CX Amsterdam, Netherlands
Lambertus A. Kiemeney - Radboud University Nijmegen
Hidetoshi Kitajima - University of Oxford
Kirsten B. Kluivers - Radboud University Nijmegen
Thomas Kocher - College Station Medical Center
Pirjo Komulainen - College Station Medical Center
Jukka Kontto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Jaspal S. Kooner - London North West Healthcare NHS Trust
Charles Kooperberg - Hutchinson
Peter Kovacs - Institute of Inland Fisheries in Potsdam-Sacrow
Jennifer Kriebel - German Ctr Diabet Res, D-85764 Munich, Germany
Helena Kuivaniemi - Sigfried & Janet Weis Ctr Res, Danville, PA 17822 USA
Sebastien Kury - College Station Medical Center
Johanna Kuusisto - University of Eastern Finland
Martina La Bianca - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, I-34137 Trieste, Italy
Markku Laakso - University of Eastern Finland
Timo A. Lakka - College Station Medical Center
Ethan M. Lange - Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Leslie A. Lange - Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Carl D. Langefeld - Supreme Council Of Health
Claudia Langenberg - University of Cambridge
Eric B. Larson - University of Washington
I-Te Lee - College Station Medical Center
Terho Lehtimaki - Fimlab
Cora E. Lewis - University of Alabama
Huaixing Li - Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
Jin Li - Stanford University
Ruifang Li-Gao - Leiden University
Honghuang Lin - Boston University
Li-An Lin - College Station Medical Center
Xu Lin - Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
Lars Lind - Uppsala University
Jaana Lindstrom - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Allan Linneberg - Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA
Yeheng Liu - College Station Medical Center
Yongmei Liu - Supreme Council Of Health
Artitaya Lophatananon - Coventry
Jian'an Luan - University of Cambridge
Steven A. Lubitz - Massachusetts Gen Hosp, Boston, MA 02114 USA
Leo-Pekka Lyytikainen - Fimlab
David A. Mackey - University of Western Australia
Pamela A. F. Madden - Washington Univ, Dept Psychiat, St Louis, MO 63110 USA
Alisa K. Manning - Massachusetts Gen Hosp, Boston, MA 02114 USA
Satu Mannisto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Gaelle Marenne - Wellcome Sanger Institute
Jonathan Marten - University of Edinburgh
Nicholas G. Martin - College Station Medical Center
Angela L. Mazul - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27514 USA
Karina Meidtner - German Ctr Diabet Res, D-85764 Munich, Germany
Andres Metspalu - University of Tartu
Paul Mitchell - University of Sydney
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Dennis O. Mook-Kanamori - Leiden University
Anna Morgan - University of Trieste
Andrew D. Morris - University of Edinburgh
Andrew P. Morris - University of Oxford
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Patricia B. Munroe - Queen Mary University of London
Mike A. Nalls - NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA
Matthias Nauck - DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany
Christopher P. Nelson - University of Leicester
Christopher P. Nelson
Matt Neville - University of Oxford
Sune F. Nielsen - Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark
Kjell Nikus - Tampere University
Pal R. Njolstad - Haukeland Hosp, Dept Pediat, N-5021 Bergen, Norway
Borge G. Nordestgaard - Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark
Ioanna Ntalla - Queen Mary University of London
Jeffrey R. O'Connel - Supreme Council Of Health
Heikki Oksa - Tampere University
Loes M. Olde Loohuis - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA 90095 USA
Roel A. Ophoff - College Station Medical Center
Katharine R. Owen - University of Oxford
Chris J. Packard - University of Glasgow
Sandosh Padmanabhan - University of Glasgow
Colin N. A. Palmer - Supreme Council Of Health
Gerard Pasterkamp - College Station Medical Center
Aniruddh P. Patel - Broad Institute
Alison Pattie - University of Edinburgh
Oluf Pedersen - University of Copenhagen
Peggy L. Peissig - Marshfield Clin Res Fdn, Marshfield, WI 54449 USA
Gina M. Peloso - Massachusetts Gen Hosp, Boston, MA 02114 USA
Craig E. Pennell - University of Western Australia
Markus Perola - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
James A. Perry - Supreme Council Of Health
John R. B. Perry - University of Cambridge
Thomas N. Person - Marshfield Clin Res Fdn, Marshfield, WI 54449 USA
Ailith Pirie - University of Cambridge
Ozren Polasek - University of Edinburgh
Danielle Posthuma - University of Amsterdam
Olli T. Raitakari - College Station Medical Center
Asif Rasheed - Ctr Noncommunicable Dis, Karachi, Pakistan
Rainer Rauramaa - College Station Medical Center
Dermot F. Reilly - Merck
Alex P. Reiner - Hutchinson
Frida Renstrom - Lund University
Paul M. Ridker - Supreme Council Of Health
John D. Rioux - Montreal Heart Institute
Neil Robertson - University of Oxford
Antonietta Robino - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, I-34137 Trieste, Italy
Olov Rolandsson - Umeå University
Igor Rudan - University of Edinburgh
Katherine S. Ruth - University of Exeter
Danish Saleheen - Ctr Noncommunicable Dis, Karachi, Pakistan
Veikko Salomaa - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Nilesh J. Samani - University of Leicester
Kevin Sandow - College Station Medical Center
Yadav Sapkota - College Station Medical Center
Naveed Sattar - University of Glasgow
Marjanka K. Schmidt - Netherlands Canc Inst, Antoni van Leewenhoek Hosp, NL-1066 CX Amsterdam, Netherlands
Pamela J. Schreiner - University of Minnesota
Matthias B. Schulze - German Ctr Diabet Res, D-85764 Munich, Germany
Robert A. Scott - University of Cambridge
Marcelo P. Segura-Lepe - University of London
Svati Shah - Duke University
Xueling Sim - Biostat
Suthesh Sivapalaratnam - Massachusetts Gen Hosp, Boston, MA 02114 USA
Kerrin S. Small - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Albert Vernon Smith - University of Iceland
Jennifer A. Smith - Supreme Council Of Health
Lorraine Southam - University of Oxford
Timothy D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Elizabeth K. Speliotes - College Station Medical Center
John M. Starr - University of Edinburgh
Valgerdur Steinthorsdottir - Amgen
Heather M. Stringham - Biostat
Michael Stumvoll - Institute of Inland Fisheries in Potsdam-Sacrow
Praveen Surendran - University of Cambridge
Leen M. 't Hart - University of Amsterdam
Katherine E. Tansey - Cardiff University
Jean-Claude Tardif - Montreal Heart Institute
Kent D. Taylor - College Station Medical Center
Alexander Teumer - Boston University
Deborah J. Thompson - University of Cambridge
Unnur Thorsteinsdottir - Amgen
Betina H. Thuesen - Capital University
Anke Toenjes - Univ Leipzig, Dept Womens & Child Hlth, Ctr Pediat Res, D-04103 Leipzig, Germany
Gerard Tromp - Sigfried & Janet Weis Ctr Res, Danville, PA 17822 USA
Stella Trompet - Leiden University
Emmanouil Tsafantakis - College Station Medical Center
Jaakko Tuomilehto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Anne Tybjaerg-Hansen - University of Copenhagen
Jonathan P. Tyrer - University of Cambridge
Rudolf Uher - Dalhousie University
Andre G. Uitterlinden - Supreme Council Of Health
Sheila Ulivi - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, I-34137 Trieste, Italy
Sander W. van der Laan - College Station Medical Center
Andries R. Van Der Leij - University of Amsterdam
Cornelia M. van Duijn - Supreme Council Of Health
Natasja M. van Schoor - University of Amsterdam
Jessica van Setten - College Station Medical Center
Anette Varbo - Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark
Tibor V. Varga - Lund University
Rohit Varma - Supreme Council Of Health
Digna R. Velez Edwards - Vanderbilt University
Sita H. Vermeulen - Radboud University Nijmegen
Henrik Vestergaard - University of Copenhagen
Veronique Vitart - University of Edinburgh
Thomas F. Vogt - MRL Merck Co Inc, Cardiometab Dis, Kenilworth, NJ 07033 USA
Diego Vozzi - College Station Medical Center
Mark Walker - Newcastle University
Feijie Wang - Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
Carol A. Wang - University of Western Australia
Shuai Wang - Boston University
Yiqin Wang - Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
Nicholas J. Wareham - University of Cambridge
Helen R. Warren - Queen Mary University of London
Jennifer Wessel - Indiana University
Sara M. Willems - University of Cambridge
James G. Wilson - University of Mississippi
Daniel R. Witte - Danish Diabet Acad, DK-5000 Odense, Denmark
Michael O. Woods - Mécanique et Engrenage Moderne
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Hanieh Yaghootkar - University of Exeter
Jie Yao - College Station Medical Center
Pang Yao - Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
Laura M. Yerges-Armstrong - Supreme Council Of Health
Robin Young - University of Cambridge
Eleftheria Zeggini - Wellcome Sanger Institute
Xiaowei Zhan - College Station Medical Center
Weihua Zhang - London North West Healthcare NHS Trust
Jing Hua Zhao - University of Cambridge
Wei Zhao - Supreme Council Of Health
Wei Zhao
He Zheng - Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
Wei Zhou - College Station Medical Center
Jerome I. Rotter - College Station Medical Center
Michael Boehnke - Biostat
Sekar Kathiresan - Broad Institute
Mark I. McCarthy - University of Oxford
Cristen J. Willer - College Station Medical Center
Kari Stefansson - Amgen
Ingrid B. Borecki - Supreme Council Of Health
Dajiang J. Liu - Pennsylvania State University
Kari E. North - Dept Epidemiol, Chapel Hill, NC 27514 USA
Nancy L. Heard-Costa - Framingham Heart Study
Tune H. Pers - University of Copenhagen
Cecilia M. Lindgren - University of Oxford
Claus Oxvig - Aarhus University
Zoltan Kutalik - University of Lausanne
Fernando Rivadeneira - Supreme Council Of Health
Ruth J. F. Loos - Supreme Council Of Health
Timothy M. Frayling - University of Exeter
Joel N. Hirschhorn - Broad Institute
Panos Deloukas - Queen Mary University of London
Guillaume Lettre - Montreal Heart Institute
EPIC-CVD Consortium
Publication Details: Nature (London), Vol.542(7640), pp.186-190
Publisher: Springer Nature
Number of pages: 5
Grant note: MC_UU_12015/2 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) SDCC 3.A Complications / Steno Diabetes Center Copenhagen (SDCC) R01 EY022310 / NEI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) R01EY022310 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) BB/F019394/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) UL1TR000124 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) ZIAAG006000 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) NF-SI-0611-10219 / National Institute for Health Research; National Institute for Health Research (NIHR) T32GM096911 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 2014105 / Doris Duke Charitable Foundation; Doris Duke Charitable Foundation (DDCF) 098395/Z/12/Z / Wellcome Trust; European Commission R01MH090553 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) U01 HG007417; U01 HG008657 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) P30DK063491 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 068545/Z/02 / Wellcome Trust; European Commission RG/14/5/30893; SP/13/2/30111; RG/08/014/24067 / British Heart Foundation UM1 CA182913; P30 CA008748 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R190-2014-3904 / Lundbeck Foundation; Lundbeckfonden HHSN268201100046C; R35 HL135824; R01 HL119443; K99 HL130580; HHSN268201300046C; R01 HL117078; T32 HL007055; N01 HC095159; R01 HL127564; K23 HL114724 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Pers Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation U01HG007417 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) S10OD018522 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32 GM096911 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) MR/K007017/1; G0700704; MR/M501633/1; MR/L01341X/1; MR/K002414/1; G9815508; MR/K026992/1; MC_PC_U127561128; MC_PC_15018; MC_UU_12015/2; MR/K006584/1; MR/L003120/1; G0600237; MC_UU_12015/1; G0601966; G0700931; MR/M501633/2; MC_PC_13040; MR/L01632X/1; MC_UU_12013/3 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01 HD057194; P2C HD050924 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) P2CHD050924 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) T32CA009156 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) N01HC095159 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) BB/F019394/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) 1233641 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission NNF16OC0021496 / Novo Nordisk Fonden; Novo Nordisk Foundation S10 OD018522 / NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30 DK063491; U01 DK062370; R01 DK072193; DP3 DK108220; R01 DK075787; P30 DK020572; R01 DK106621; R01 DK107904; R01 DK093757; R01 DK089256 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) UL1 TR001881; KL2 TR001109; UL1 TR000124 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01 MH090553 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) K23HL114724 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
Identifiers: 9940164408331
Academic Unit: King Abdulaziz University; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article