Abstract
Pulicaria species, such as Pulicaria undulata, are rich in sesquiterpene lactones. The methylene chloride/methanol (1: 1) extract of P. undulata resulted in the isolation of new sesquiterpenes (1-4), as well as previously reported metabolites (5-14). Structures were elucidated by spectroscopic analyses. Using a mouse peritoneal macrophage bioassay, lipopolysaccharide-induced nitric oxide inhibition was observed with the eudesman-type sesquiterpene 1 beta, 4 beta-dihydroxy-5 alpha H, 7 alpha H, 8 alpha-guaia-10(14), 11(13)-dien-8 beta, 12-olide (11) at an EC50 of 7.2 mu M. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.