Abstract
Treatment of diabetes mellitus by oral α-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects. Since the discovery of the drugs more than three decades ago, no significant progress has been made in the drug development area of anti-diabetic α-glucosidase inhibitors. Despite existence of a wide chemical diversity of α-glucosidase inhibitors identified to date, majority of them are simply piled up in publications and reports thus creating a haystack destined to be forgotten in the scientific literature without given consideration for further development into drugs. This review finds those “needles” in that haystack and lays groundwork for highlighting promising α-glucosidase inhibitors from the literature that may potentially become suitable candidates for pre-clinical or clinical trials while drawing attention of the drug development community to consider and take already-identified promising α-glucosidase inhibitors into the next stage of drug development.
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•Acarbose, voglibose and miglitol are the only α-glucosidase inhibitors clinically used for diabetes mellitus treatment.•The drugs have efficacy problems and unwanted side effects with no new drug development yet in this area.•Many promising α-glucosidase inhibitors identified to date are simply piled up in publications.•This work discusses promising α-glucosidase inhibitors that could become candidates for preclinical or clinical trials.