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Reaction of mercaptoacetate and halides containing activated methylenes with thiocarbamoylimidates: A novel approach to the synthesis of aminothiazole derivatives
Journal article   Peer reviewed

Reaction of mercaptoacetate and halides containing activated methylenes with thiocarbamoylimidates: A novel approach to the synthesis of aminothiazole derivatives

K Dridi, M L El Efrit, B Baccar and H Zantour
Synthetic communications, Vol.29(11), pp.2019-2026
01/01/1999
DOI: https://doi.org/10.1080/00397919908086191

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The reaction of N-thiocarbamoylimidates (1) under bar with methyl thioglycolate leads to the formation of 4-arylamino-5-methoxycarbonylthiazoles (2) under bar. The condensation of the same imidates (1) under bar on ethyl bromoacetate, benzyl bromide and chloroacetonitrile provides the corresponding 2-arylaminothiazoles (4) under bar.

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