Abstract
The reaction of 5-bromo-4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (1) with phosphorus ylides 2a,b afforded the new phosphonium ylides 7a,b. Wittig - Honer reagent 3 reacts with 1 to give the olefinic product 8. On the other hand, the dimeric compound 9 and the alkylated products 10, 11 were isolated from the reaction of 1 with dialkyl phosphite 4, trialkyl phosphite 5 and tris(dimethylamino) phosphine 6. Possible reaction mechanisms are considered, and the structural assignments are based on analytical and spectroscopic evidence. [Hoda A. Abdel - Malek, Marwa. S. Salem, and Leila S. Boulos Reactions of 5-Bromo-4,6-Dimethyl-2-Thioxo-1,2- Dihydropyridine -3- Carbonitrile with Organophosphorus Reagents. Life Science Journal 2012; 9(1):695-700]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 100