Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin; Elena Galea; András Lakatos; James P O'Callaghan; Gabor C Petzold; Alberto Serrano-Pozo; Christian Steinhäuser; Andrea Volterra; Giorgio Carmignoto; Amit Agarwal; Nicola J Allen; Alfonso Araque; Luis Barbeito; Ari Barzilai; Dwight E Bergles; Gilles Bonvento; Arthur M Butt; Wei-Ting Chen; Martine Cohen-Salmon; Colm Cunningham; Benjamin Deneen; Bart De Strooper; Blanca Díaz-Castro; Cinthia Farina; Marc Freeman; Vittorio Gallo; James E Goldman; Steven A Goldman; Magdalena Götz; Antonia Gutiérrez; Philip G Haydon; Dieter H Heiland; Elly M Hol; Matthew G Holt; Masamitsu Iino; Ksenia V Kastanenka; Helmut Kettenmann; Baljit S Khakh; Schuichi Koizumi; C Justin Lee; Shane A Liddelow; Brian A MacVicar; Pierre Magistretti; Albee Messing; Anusha Mishra; Anna V Molofsky; Keith K Murai; Christopher M Norris; Seiji Okada; Stéphane H R Oliet; João F Oliveira; Aude Panatier; Vladimir Parpura; Marcela Pekna; Milos Pekny; Luc Pellerin; Gertrudis Perea; Beatriz G Pérez-Nievas; Frank W Pfrieger; Kira E Poskanzer; Francisco J Quintana; Richard M Ransohoff; Miriam Riquelme-Perez; Stefanie Robel; Christine R Rose; Jeffrey D Rothstein; Nathalie Rouach; David H Rowitch; Alexey Semyanov; Swetlana Sirko; Harald Sontheimer; Raymond A Swanson; Javier Vitorica; Ina-Beate Wanner; Levi B Wood; Jiaqian Wu; Binhai Zheng; Eduardo R Zimmer; Robert Zorec; Michael V Sofroniew; Alexei Verkhratsky; Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap

doi:10.1038/s41593-020-00783-4

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Reactive astrocyte nomenclature, definitions, and future directions

Journal article

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Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin, Elena Galea, András Lakatos, James P O'Callaghan, Gabor C Petzold, Alberto Serrano-Pozo, Christian Steinhäuser, Andrea Volterra, Giorgio Carmignoto, Amit Agarwal, …

Nature neuroscience, Vol.24(3), pp.312-325

01/03/2021

DOI: https://doi.org/10.1038/s41593-020-00783-4

PMCID: 8007081

PMID: 33589835

Abstract

Aging - pathology

Animals

Astrocytes - pathology

Brain - pathology

Brain Diseases - pathology

Brain Injuries - pathology

Humans

Spinal Cord - pathology

Spinal Cord Injuries - pathology

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

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Title: Reactive astrocyte nomenclature, definitions, and future directions
Creators - without role: Carole Escartin - University of Paris-Saclay
Elena Galea - Universitat Autònoma de Barcelona
András Lakatos - University of Cambridge
James P O'Callaghan - National Institute for Occupational Safety and Health
Gabor C Petzold - German Center for Neurodegenerative Diseases
Alberto Serrano-Pozo - Massachusetts General Hospital
Christian Steinhäuser - University of Bonn
Andrea Volterra - University of Lausanne
Giorgio Carmignoto - Neuroscience Institute
Amit Agarwal - Chica and Heinz Schaller Foundation
Nicola J Allen - Salk Institute for Biological Studies
Alfonso Araque - University of Minnesota
Luis Barbeito - Institut Pasteur de Montevideo
Ari Barzilai - Tel Aviv University
Dwight E Bergles - Johns Hopkins Medicine
Gilles Bonvento - University of Paris-Saclay
Arthur M Butt - University of Portsmouth
Wei-Ting Chen - KU Leuven
Martine Cohen-Salmon - Center for Interdisciplinary Research in Biology
Colm Cunningham - Trinity College Dublin
Benjamin Deneen - Baylor College of Medicine
Bart De Strooper - VIB-KU Leuven Center for Brain & Disease Research
Blanca Díaz-Castro - UK Dementia Research Institute
Cinthia Farina - Institute of Experimental Neurology (INSpe) and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
Marc Freeman - Vollum Institute
Vittorio Gallo - Children's National
James E Goldman - Columbia University
Steven A Goldman - University of Rochester Medical Center
Magdalena Götz - Munich Cluster for Systems Neurology
Antonia Gutiérrez - Instituto de Investigación Biomédica de Málaga
Philip G Haydon - Tufts University
Dieter H Heiland - University of Freiburg
Elly M Hol - University Medical Center Utrecht
Matthew G Holt - VIB-KU Leuven Center for Brain & Disease Research
Masamitsu Iino - Nihon University
Ksenia V Kastanenka - Massachusetts General Hospital
Helmut Kettenmann - Max Delbrück Center for Molecular Medicine
Baljit S Khakh - University of California, Los Angeles
Schuichi Koizumi - University of Yamanashi
C Justin Lee - Institute for Basic Science
Shane A Liddelow - Neurosciences Institute
Brian A MacVicar - Vancouver Coastal Health
Pierre Magistretti - King Abdullah University of Science and Technology
Albee Messing - University of Wisconsin–Madison
Anusha Mishra - Oregon Health & Science University
Anna V Molofsky - University of California, San Francisco
Keith K Murai - McGill University Health Centre
Christopher M Norris - University of Kentucky
Seiji Okada - Kyushu University
Stéphane H R Oliet - Neurocentre Magendie
João F Oliveira - University of Minho
Aude Panatier - Neurocentre Magendie
Vladimir Parpura - University of Alabama at Birmingham
Marcela Pekna - University of Gothenburg
Milos Pekny - University of Gothenburg
Luc Pellerin - University of Poitiers
Gertrudis Perea - Instituto Cajal
Beatriz G Pérez-Nievas - King's College London
Frank W Pfrieger - Institute of Cellular and Integrative Neurosciences
Kira E Poskanzer - University of California, San Francisco
Francisco J Quintana - Brigham and Women's Hospital
Richard M Ransohoff - Third Dimension Technologies
Miriam Riquelme-Perez - University of Paris-Saclay
Stefanie Robel - Virginia Tech
Christine R Rose - Heinrich Heine University Düsseldorf
Jeffrey D Rothstein - Johns Hopkins University
Nathalie Rouach - Center for Interdisciplinary Research in Biology
David H Rowitch - Wellcome/MRC Cambridge Stem Cell Institute
Alexey Semyanov - Institute of Bioorganic Chemistry
Swetlana Sirko - Helmholtz Zentrum München
Harald Sontheimer - Carilion Roanoke Memorial Hospital
Raymond A Swanson - University of California, San Francisco
Javier Vitorica - Biomedical Research Networking Center on Neurodegenerative Diseases
Ina-Beate Wanner - Semel Institute for Neuroscience & Human Behavior, IDDRC, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
Levi B Wood - The Wallace H. Coulter Department of Biomedical Engineering
Jiaqian Wu - The University of Texas Health Science Center
Binhai Zheng - University of California, San Diego
Eduardo R Zimmer - Universidade Federal do Rio Grande do Sul
Robert Zorec - University of Ljubljana
Michael V Sofroniew - University of California, Los Angeles
Alexei Verkhratsky - University of Manchester
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Publication Details: Nature neuroscience, Vol.24(3), pp.312-325
Grant note: MC_PC_17230 / Medical Research Council R01 GM123971 / NIGMS NIH HHS CC999999 / Intramural CDC HHS R01 NS102807 / NINDS NIH HHS R01 NS036692 / NINDS NIH HHS RF1 AG027297 / NIA NIH HHS R56 AG060974 / NIA NIH HHS R01 NS105807 / NINDS NIH HHS R01 AG066171 / NIA NIH HHS K08 AG064039 / NIA NIH HHS MR/P008658/1 / Medical Research Council R01 AG056998 / NIA NIH HHS R01 NS084030 / NINDS NIH HHS R01 NS110690 / NINDS NIH HHS R01 DA048822 / NIDA NIH HHS RF1 AG061774 / NIA NIH HHS R01 MH104701 / NIMH NIH HHS
Identifiers: 9945895408331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article