Abstract
► Engineered NPs are increasingly produced nowadays as the result of the rapid development in nanotechnology. ► Drug delivery, cancer therapy, and tissue engineering are the major uses of engineered NPs in medicine. ► Unintended exposure to engineered NPs would result in various diversified effects among workers and consumers. ► Regulatory health risk assessment of engineered NPs becomes mandatory due to their wide production and commercial use.
Over recent decades, engineered nanoparticles are increasingly produced as the result of the rapid development in nanotechnology. They are currently used in a wide range of industrial and public sectors including healthcare, agriculture, transport, energy, materials, and information and communication technologies. As the result, an increasing concern has been raised over the potential impacts of engineered nanoparticles to human health. In the light of this, it is the purpose of the present review to discuss: (1) novel properties of engineered nanoparticles particularly in biomedical sciences, (2) most recently reported adverse effects of manufactured nanoparticles on human health and (3) different aspects of toxicological risk assessment of these nanoparticles.