Abstract
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•Design and synthesis of structurally fascinating β-lactam grafted spiroheterocycles.•Spirocycloadducts were achieved in excellent yields via cycloaddition methodology.•Regio- and stereochemistry of compounds determination by spectroscopic studies.
Synthesis of structurally fascinating β-lactam tethered spiroheterocyclic hybrids have been achieved with complete regio- and diastereoselectively in excellent yields via a one-pot three component 1,3-dipolar cycloaddition strategy employing azetidin-2-yl-malononitriles as dipolarophiles. The overall transformation generates four stereogenic carbons via the formation of three new bonds in single operation. Structural elucidation of the synthesized compounds was executed by NMR spectroscopic studies and the regio-/stereoselectivity has been ascertained by single crystal X-ray diffraction analysis.