Abstract
An expedient regioselectivesynthesis of novel mono, C-2-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding steps starting from dimedone, while the symmetrical aliphatic and aryl bis-azides were derived from appropriate dibromides in the presence of sodium azide in dry DMF. The synthesized mono and C-2-symmetric bis-macromolecules have been elucidated by H-1, C-13, elemental and mass spectroscopic analysis. The antioxidant activity of synthesized compounds has also been investigated. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.