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Regulation of NK cell activity by 2B4, NTB-A and CRACC
Journal article   Peer reviewed

Regulation of NK cell activity by 2B4, NTB-A and CRACC

Maren Claus, Stephan Meinke, Rauf Bhat and Carsten Watzl
Frontiers in bioscience, Vol.13(3), pp.956-965
01/01/2008
DOI: https://doi.org/10.2741/2735
PMID: 17981603

Abstract

Animals Antigens, CD - metabolism Autoimmune Diseases - metabolism Humans Immune System Killer Cells, Natural - metabolism Lymphocyte Activation Membrane Glycoproteins - metabolism Mice Models, Biological Receptors, Cell Surface - metabolism Receptors, Immunologic - metabolism Signal Transduction Signaling Lymphocytic Activation Molecule Family Signaling Lymphocytic Activation Molecule Family Member 1 Th1 Cells - metabolism Th2 Cells - metabolism
2B4, NTB-A and CRACC are members of the recently defined family of SLAM-related receptors. Here we review the role of these receptors for the regulation of Natural Killer cell function and describe the current knowledge about the signal transduction of these receptors. Finally, we critically analyze some controversial data about the function of 2B4 in mouse and man.

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