Abstract
To compare the quantitative data of multiparametric prostatic MRI with Gleason scores of histopathological analysis.
One hundred twenty-two patients performed Multiparametric MRI of the prostate. Functional MRI quantitative data (including diffusion with mean ADC value and spectroscopic metabolic ratio) where the DWI is employing b 50, 400, 800, 1000 and 2000sec/mm2 and multivoxel MR spectroscopy compared with of Gleason scores of histopathological results. Malignant cases are classified into three groups according to their Gleason score as group I with Gleason score ≤6, group II Gleason score 7, while Gleason score 8–10 stratified as Group III.
The histopathological analysis reveals 78 malignant cases and 44 benign Cases. The significant statistical difference between group I and the other two groups (p<0.001) regarding the quantitative mean ADC value and metabolic spectroscopic ratio. No significant statistical difference between group II and III with p=0.2 for mean ADC difference and p=0.8 for the metabolic spectroscopic ratio with a weak negative correlation between ADCand Gleason score [rs=−0.26] and significant positive correlation (p=0.02) for MRSI metabolic ratio [rs=0.2].
The quantitative data of functional imaging of the prostate is reliable in evaluating prostatic cancer aggressiveness and proper construction of therapeutic plan.