Abstract
The first total synthesis and structure revision of (-)-11 beta-hydroxycurvularin (1b), a macrolide possessing a beta-hydroxyketone moiety, were accomplished. The beta-hydroxyketone moiety in this natural product was introduced by cleavage of the N-O bond in an isoxazoline ring that was formed diastereoselectively in a 1,5-remote stereocontrolled fashion by employing intramolecular nitrile oxide cycloaddition.