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Resolution of (4RS,5RS)-4,5-diphenylimidazolidine-2-thione using pentafluorophenyl active esters
Journal article   Peer reviewed

Resolution of (4RS,5RS)-4,5-diphenylimidazolidine-2-thione using pentafluorophenyl active esters

Anna Andreou, Najla Al Shaye, Hannah Brown and Jason Eames
Tetrahedron letters, Vol.51(52), pp.6935-6938
29/12/2010
DOI: https://doi.org/10.1016/j.tetlet.2010.10.157

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
(4RS,5RS)-4,5-Diphenylimidazolidine-2-thione is resolved efficiently by treatment with NaHMDS and an enantiomerically pure pentafluorophenyl active ester. The levels of diastereocontrol were excellent (up to 90% de). (C) 2010 Elsevier Ltd. All rights reserved.

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