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Resolution of Pentafluorophenyl Active Esters Using (S)-4-Phenyloxazolidin-2-thione
Journal article   Peer reviewed

Resolution of Pentafluorophenyl Active Esters Using (S)-4-Phenyloxazolidin-2-thione

Najla Al Shaye, Tom W. Broughton, Elliot Coulbeck and Jason Eames
Synlett, Vol.2009(6), pp.960-964
01/04/2009
DOI: https://doi.org/10.1055/s-0028-1088218

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A series Of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4-phenyloxazolidin-2-thione. The levels of diastereocontrol were found to be excellent (>86% de at similar to 30% conversion).

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