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Resolution of pentafluorophenyl esters using oxazolidin-2-ones
Journal article   Peer reviewed

Resolution of pentafluorophenyl esters using oxazolidin-2-ones

Najla Al Shaye and Jason Eames
Tetrahedron letters, Vol.51(45), pp.5892-5895
10/11/2010
DOI: https://doi.org/10.1016/j.tetlet.2010.08.109

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A series of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4-phenyloxazolidin-2-one. The levels of diastereocontrol were found to be excellent (80-96% de) at similar to 40% conversion. (C) 2010 Elsevier Ltd. All rights reserved.

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