Abstract
Background/aim: Extracellular Amyloid beta plaque formation and intracellular tau hyperphosphorylation in brain are hallmarks of AD pathology. Studies have indicated protective effects of resveratrol against AD. However, the underlying mechanisms are poorly understood. Here we examined the effect of resveratrol on amyloid beta (A beta), tau protein, acetylcholine esterase (AchE), oxidative stress and inflammation to understand mechanisms in protective effects of resveratrol using aluminum chloride (AlCl3) induced AD inrat model.
Materials and method: Sixty Rats were divided into six groups (ten rats each). Rats were treated orally with AlCl3 to induced AD. Rats were treated before and after AlCl3 with resveratrol as protective and therapeutic effect.
Results: AlCl3 treatment significantly induced the pathological characteristics of AD in the rats as evident from the significantly increased serum A beta, tau protein, AchE, CRP, IL-6, TNF-alpha, TGF-beta, and MDA levels and significantly decreased catalase and SOD activities. Marked histological alterations were noticed in brain tissues of AD rats. Oral treatment with resveratrol for 45 days before or after induction of AD resulted in a significant reversal of studied parameters. Moreover, AD rats treated with pharmacological drug, ebixa had comparable effects to that of resveratrol. The underlying mechanism in the protective effects of resveratrol against AD appears to involve its modulatory effects on A beta, tau, oxidative stress and inflammation. This is the first study to simultaneously measure the multiple pathological markers to confirm the therapeutic and preventive potential of resveratrol against AD.
Conclusion: Our finding shed the light on the promising therapeutic and protective effect of resveratrol in attenuation AD complications through its antioxidant and anti-inflammatory effect.