Abstract
To assess the correlation between disability progression assessed by expanded disability status scale (EDSS) and peripapillary retinal nerve fiber layer thickness (RNFLT), macular thickness and macular volume obtained by spectral domain OCT (SDOCT) in patient with relapsing–remitting multiple sclerosis.
We conducted a cross sectional study by recruiting 104 with relapsing–remitting MS patients and 51 healthy controls. Patients' clinical characteristics and neurologic disability was recorded from the subject clinical records. All patients had complete neuro-ophthalmic and neurological assessments. SDOCT performed to obtain peripapillary RNFLT, macular thickness and volume.
There was a statistically significant correlation between the mean EDSS scores and the average RNFLT (p=0 .006; r=−0.268) along with superior (p=0.020; r=−0.228), inferior (p=0.007; r=−0.262) and temporal (p=0.031; r=−0.212) quadrants. However, macular thickness (p=0.205; r=−0.125) and volume (p=0.178; r=−0.133) were not significantly correlated with EDSS scores.
Our study showed a significant correlation between RNFLT and disability progression assessed by mean of EDSS in patients with relapsing–remitting MS. RNFLT can be a useful tool to estimate neurological disability in newly diagnosed patients or patients with early RRMS.
•We have investigated the correlation between retinal nerve fiber layer thickness (RNFLT) and expanded disability status scale (EDSS) in a cohort of early relapsing-remitting MS patients.•There was a significant correlation between RNFLT and EDSS particularly in patients without history of optic neuritis.•RNFT can be a useful measure of neurologic disability in patients with early relapsing-remitting MS and mild disability with no history of optic neuritis.