Abstract
Hyperthermia cancer atherapy designed by magnetic particles as heating nano-mediators has been greatly applied for in vitro purposes to make reliable and certain conditions for in vivo trials. This intracellular treatment has found higher efficiency as compared to conventional ones due to generating heat locally through superparamagnetic nanoparticles for inaccessible tumors with minimal damage to the healthy cells nearby. The main challenges of this novel cancer therapy are the enhancement of heating power of such nanoparticles and the control of the local tumoral temperature. Those hyperthermia factors basically derived from magnetic nanoparticles as well as magnetic field. Thereby, the efficiency of magnetic hyperthermia is principally dependent on the proper determination of their features. This study tried to provide a comprehensive evaluation on the magnetic hyperthermia therapy through the determination of magnetic nanoparticles such as surface chemistry, intrinsic and extrinsic magnetic properties. In addition, the features of the magnetic field that substantially play on induction heating power and hyperthermia temperature are reviewed. (C) 2017 Elsevier Ltd. All rights reserved.