Abstract
Objective: The aim of our study was to determine the genetic associations between polymorphisms of the IL1β gene (−511C/T and +3953C/T) and IL6 gene (−174G/C) with disease susceptibility and severity in patients with rheumatoid arthritis (RA) in ethnic Kashmiri population.
Methods: Allele and genotype frequencies of IL1β −511 C/T, IL1β +3953 C/T and IL6 −174 G/C polymorphisms were compared between 150 RA patients and 200 healthy controls by using PCR-RFLP method.
Results: We did not find any significant association between IL1b +3953 C/T and IL6 −174 G/C polymorphism and Rheumatoid Arthritis risk (p > 0.05), but IL1β +3953 CT genotype was associated significantly with increased SJC and ESR and IL6 −174 GG genotype was associated significantly with increased ESR. However IL1b −511C/T polymorphism was significantly associated with rheumatoid arthritis risk and the carriers of IL1β −511 'C' allele (CC and TC genotypes) appeared to have lower risk for RA development.
Conclusion: Our findings suggest that the IL1b −511 'C' allele has a protective role from disease development. Furthermore our results suggest a possible role of IL1b +3953 CT and IL6 −174 GG genotypes as disease activity markers of rheumatoid arthritis.