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Rhodium(III)-Catalyzed in situ Oxidizing Directing Group-Assisted C-H Bond Activation and Olefination: A Route to 2-Vinylanilines
Journal article   Peer reviewed

Rhodium(III)-Catalyzed in situ Oxidizing Directing Group-Assisted C-H Bond Activation and Olefination: A Route to 2-Vinylanilines

Krishnamoorthy Muralirajan, Radhakrishnan Haridharan, Sekar Prakash and Chien-Hong Cheng
Advanced synthesis & catalysis, Vol.357(4), pp.761-766
09/03/2015

Abstract

Chemistry Chemistry, Applied Chemistry, Organic Physical Sciences Science & Technology
A new and efficient method for the synthesis of 2-vinylanilines from the reaction of arylhydrazine hydrochlorides with alkenes and diethyl ketone via a rhodium-catalyzed C-H activation is described. The oxidant-free olefination reaction involves the in situ generation of an N N-(CRR2)-R-1 moiety as the oxidizing directing group thus providing an easy access to 2-vinylanilines.

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