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Ring-Opening Copolymerization of Maleic Anhydride with Functional Epoxides: Poly(propylene fumarate) Analogues Capable of Post-Polymerization Modification
Journal article   Peer reviewed

Ring-Opening Copolymerization of Maleic Anhydride with Functional Epoxides: Poly(propylene fumarate) Analogues Capable of Post-Polymerization Modification

Yusheng Chen, James A Wilson, Shannon R Petersen, Derek Luong, Sahar Sallam, Jialin Mao, Chrys Wesdemiotis and Matthew L Becker
Angewandte Chemie (International ed.), Vol.57(39), pp.12759-12764
24/09/2018
DOI: https://doi.org/10.1002/anie.201807419
PMID: 30080946

Abstract

Animals Cell Line Cell Membrane Permeability - drug effects Click Chemistry Epoxy Compounds - chemistry Fumarates - chemical synthesis Fumarates - chemistry Fumarates - pharmacology Maleic Anhydrides - chemistry Mice Microscopy, Fluorescence Polymerization Polypropylenes - chemical synthesis Polypropylenes - chemistry Polypropylenes - pharmacology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry
Three functional epoxides were copolymerized with maleic anhydride to yield degradable poly(propylene fumarate) analogues. The polymers were modified post-polymerization and post-printing with either click-type addition reactions or UV deprotection to either attach bioactive species or increase the hydrophilicity. Successful dye attachment, induced wettability, and improved cell spreading show the viability of these analogues in biomaterials applications.

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