Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Tomas Radivoyevitch; Robert M. Dean; Bronwen E. Shaw; Ruta Brazauskas; Heather R. Tecca; Remco J. Molenaar; Minoo Battiwalla; Bipin N. Savani; Mary E.D. Flowers; Kenneth R. Cooke; Betty K. Hamilton; Matt Kalaycio; Jaroslaw P. Maciejewski; Ibrahim Ahmed; Görgün Akpek; Ashish Bajel; David Buchbinder; Jean-Yves Cahn; Anita D’Souza; Andrew Daly; Zachariah DeFilipp; Siddhartha Ganguly; Mehdi Hamadani; Robert J. Hayashi; Peiman Hematti; Yoshihiro Inamoto; Nandita Khera; Tamila Kindwall-Keller; Heather Landau; Hillard Lazarus; Navneet S. Majhail; David I. Marks; Richard F. Olsson; Sachiko Seo; Amir Steinberg; Basem M. William; Baldeep Wirk; Jean A. Yared; Mahmoud Aljurf; Muneer H. Abidi; Heather Allewelt; Amer Beitinjaneh; Rachel Cook; Robert F. Cornell; Joseph W. Fay; Gregory Hale; Jennifer Holter Chakrabarty; Sonata Jodele; Kimberly A. Kasow; Anuj Mahindra; Adriana K. Malone; Uday Popat; J. Douglas Rizzo; Harry C. Schouten; Anne B. Warwick; William A. Wood; Mikkael A. Sekeres; Mark R. Litzow; Robert P. Gale; Shahrukh K. Hashmi

doi:10.1016/j.leukres.2018.07.016

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Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Journal article

Peer reviewed

Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Tomas Radivoyevitch, Robert M. Dean, Bronwen E. Shaw, Ruta Brazauskas, Heather R. Tecca, Remco J. Molenaar, Minoo Battiwalla, Bipin N. Savani, Mary E.D. Flowers, Kenneth R. Cooke, …

Leukemia research, Vol.74, pp.130-136

01/11/2018

DOI: https://doi.org/10.1016/j.leukres.2018.07.016

PMCID: PMC6219911

PMID: 30055822

Abstract

AML

Autotransplant

CIBMTR

MDS

New cancers

SEER

Therapy-related

•TBI conditioning for autotransplantation is associated with higher risks of t-MN.•Risks of t-MN after autotransplantation for NHL are increasing.•Autotransplantation increases risks of MDS more than AML. Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). 9028 recipients of hematopoietic cell autotransplants (1995–2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. 335 MDS/AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR = 4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR = 2.5 [1.1, 2.5]); (2) ≥3 versus 1 line of chemotherapy for NHL (HR = 1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005–2010 versus 1995–1999 (HR = 2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/MDS in HL, NHL and PCM to be 5–10 times the background rate. In contrast, relative risks were 10–50 for AML and approximately 100 for MDS in the autotransplant cohort. There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.

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Title: Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma
Creators - without role: Tomas Radivoyevitch - Cleveland Clinic
Robert M. Dean - Cleveland Clinic
Bronwen E. Shaw - Medical College of Wisconsin
Ruta Brazauskas - Medical College of Wisconsin
Heather R. Tecca - Medical College of Wisconsin
Remco J. Molenaar - Cleveland Clinic
Minoo Battiwalla - National Heart Lung and Blood Institute
Bipin N. Savani - Vanderbilt University Medical Center
Mary E.D. Flowers - Fred Hutch Cancer Center
Kenneth R. Cooke - Sidney Kimmel Comprehensive Cancer Center
Betty K. Hamilton - Cleveland Clinic
Matt Kalaycio - Cleveland Clinic
Jaroslaw P. Maciejewski - Cleveland Clinic
Ibrahim Ahmed - Children's Mercy Hospital
Görgün Akpek - Rush University Medical Center
Ashish Bajel - Royal Melbourne Hospital
David Buchbinder - Children's Hospital of Orange County
Jean-Yves Cahn - Centre Hospitalier Universitaire de Grenoble
Anita D’Souza - Medical College of Wisconsin
Andrew Daly - Baker Hughes
Zachariah DeFilipp - Massachusetts General Hospital
Siddhartha Ganguly - University of Kansas Medical Center
Mehdi Hamadani - Medical College of Wisconsin
Robert J. Hayashi - Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, United States
Peiman Hematti - UW Health University Hospital
Yoshihiro Inamoto - STEM
Nandita Khera - Winneshiek Medical Center
Tamila Kindwall-Keller - University of Virginia Health System
Heather Landau - Medical College of Wisconsin
Hillard Lazarus - Case Western Reserve University
Navneet S. Majhail - Cleveland Clinic
David I. Marks - Adult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom
Richard F. Olsson - Karolinska Institutet
Sachiko Seo - Department of Hematology & Oncology, National Cancer Research Center East, Chiba, Japan
Amir Steinberg - Mount Sinai Hospital
Basem M. William - Ohio State Medical Center, Columbus, OH, United States
Baldeep Wirk - Seattle Cancer Care Alliance
Jean A. Yared - Centre Hospitalier Universitaire de Grenoble
Mahmoud Aljurf - Department of Oncology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
Muneer H. Abidi - Wayne State University
Heather Allewelt - Medical College of Wisconsin
Amer Beitinjaneh - University of Miami
Rachel Cook - Sidney Kimmel Comprehensive Cancer Center
Robert F. Cornell - Vanderbilt University Medical Center
Joseph W. Fay - Baylor University Medical Center
Gregory Hale - Johns Hopkins All Children's Hospital
Jennifer Holter Chakrabarty - University of Oklahoma
Sonata Jodele - Cincinnati Children's Hospital Medical Center
Kimberly A. Kasow - University of North Carolina at Chapel Hill
Anuj Mahindra - Scripps
Adriana K. Malone
Uday Popat - MD Anderson Cancer Center, Houston, TX, United States
J. Douglas Rizzo - Medical College of Wisconsin
Harry C. Schouten - Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands
Anne B. Warwick - Uniformed Services University of the Health Sciences
William A. Wood - University of North Carolina at Chapel Hill
Mikkael A. Sekeres - Cleveland Clinic
Mark R. Litzow - Mayo Clinic in Arizona
Robert P. Gale - Imperial College London
Shahrukh K. Hashmi - Department of Oncology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
Publication Details: Leukemia research, Vol.74, pp.130-136
Publisher: Elsevier Ltd
Identifiers: 9947816508331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article