Abstract
To evaluate the efficacy of enamel matrix derivative (EMD) with bioactive glass (BG) in the management of periodontal osseous defects. The addressed focused question was "Does the use of EMD with BG, improve its efficacy in the management of periodontal defects in comparison to EMD alone?" Databases were searched up to December 2019 using different combinations of MESH words. Six randomized clinical trials were included. One study showed significantly better periodontal outcomes for BG as an adjunct to EMD as compared to EMD alone. However, in two studies, improvement in the periodontal parameters for BG application as an adjunct to EMD and EMD alone were comparable. One clinical trial indicated significant improvement in clinical periodontal measures with the use of adjunctive EMD to BG compared with BG alone. However, one study showed equal outcomes between adjunctive EMD and BG alone. One study showed significant clinical improvement for BG compared with EMD. In conclusion, it remains unclear whether the efficacy of EMD in the management of periodontal osseous defects is improved when it is used in combination with BG as compared to when EMD is used alone given that the number of selected studies was relatively low and reported parameters were inconsistent.