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Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes
Journal article   Peer reviewed

Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

Yuanyuan Huang, Xin Fang, Xiaoxi Lin, Huaifeng Li, Weiming He, Kuo-Wei Huang, Yaofeng Yuan and Zhiqiang Weng
Tetrahedron, Vol.68(48), pp.9949-9953
02/12/2012
DOI: https://doi.org/10.1016/j.tet.2012.09.083

Abstract

Copper catalyst Electrophilic trifluoromethylation reaction Trifluoromethylarenes
An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. [Display omitted]

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